Patient non-adherence to medication is one of the major challenges in the treatment of chronic conditions - including mental illnesses and disorders. Lack of therapeutic adherence can affect up to nearly 60% patients with depression. Non-adherence depends on a number of factors and is a complex phenomenon: it can relate to one or several recommendations, be continuous or intermittent, intentional or not. Non-adherence leads to numerous negative consequences, both health and social. In patients with depression, it can increase the frequency of hospitalisation and the risk of symptom recurrence, and is also associated with greater severity of depression, less frequent therapeutic response and remission, and lower levels of functioning. Adverse drug reactions appear to be one reason for non-adherence. This article presents a review of the literature on treatment tolerance with various antidepressants. Antidepressants were analysed in terms of their risk of causing those side effects that patients in studies most frequently reported as a reason for discontinuing psychopharmacotherapy. Among people with anxiety disorders, non-adherence to medication is also common, depending on a number of variables. Knowledge of the factors negatively affecting adherence among patients with depression and anxiety disorders and appropriate interventions may contribute to improving the outcome of mental illness and disorders.
https://ptfarm.pl/pub/File/Farmacja%20Polska/2009/11-2009/02%20%20Adherence.pdf